# eGFR using Updated MDRD Equation (2006)

Calculate eGFR using the updated MDRD (4 Variables, and Standardized creatinine) Equation (2006)

### Questions

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) began a multicenter study named the Modification of Diet in Renal Disease (MDRD). It was designed to assess the acceptance, safety, and efficacy of restricted protein and phosphorus diets in patients with chronic renal disease. One of the results of this study is the development of the MDRD equation. The original MDRD equation had been announced in 1999 and developed based on 6 variables: serum creatinine, age, sex, ethnicity, and serum levels of urea and albumin [8].
Original MDRD (6 Variables) Equation = 170 * (Scr)-0.999 * (Age)-0.176 * 0.762 [if female] * 1.180 [if black] * [SUNb]-0.170 * [Alb]+0.318

Subsequently, in 2000 a simplified equation including 4 variables had been proposed to simplify its clinical use, and it was consisting of age, sex, ethnicity, and serum creatinine.
Simplified MDRD (4 Variables) eGFR (ml/min/1.73m2) = 186 * [Scr]-1.154 * [Age] -0.203 * [0.742 if female] * [1.21 if black]

After the great work on the creatinine standardization program , it was necessary to re-express the MDRD equation to fulfil the new development. Then the updated MDRD equation has been announced in 2006.
The estimated glomerular filtration rate (GFR) is a quick way to assess how well the kidneys filter toxins from the blood, balance fluids, control the production of red blood cells, and more. Estimated glomerular filtration rate (eGFR) is one of the primary diagnostic methods for detecting and managing kidney diseases. To find the eGFR, healthcare professionals use a blood test and a special calculator.
MDRD like other eGFR equations has two benefits in general; help in the staging of Chronic Kidney Diseases (CKD), assessment of renal functions of the potential kidney donors and adjustment of drug dosing in renal impairment cases . Kidney Disease Outcomes Quality Initiative (K/DOQI) was the first organization that recommended using the simplified MDRD equation in clinical practice in 2002 and after introducing the creatinine standardization program in 2006 , many other guidelines have recommended the updated MDRD equation.
Equation: eGFR using the Updated MDRD (4 Variables, and Standardized creatinine) Equation (2006) = 175 * [Scr]-1.154 * [Age] -0.203 * [0.742 if female] * [1.21 if black]
where:
Scr = standardized serum creatinine in mg/dL
Age (years)

## References

Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F.

Intern Med. 2006 Aug 15;145(4):247-54. doi: 10.7326/0003-4819-145-4-200608150-00004

Muhamad Ali Alherk, Mohammad Ammar M. K. Yahia, Kaumudi Bery.

doi: 10.36347/sjams.2022.v10i07.008

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