MADIT-ICD Benefit Score
Predicted Benefit of an Implantable Cardioverter-Defibrillator for primary prevention
Current guidelines provide a Class I recommendation for primary implantation of an ICD in patients with left ventricular ejection fraction (LVEF) ≤ 35%. However, the benefit of the ICD for primary prevention is not uniform due to differences in the risk of ventricular tachyarrhythmia (VT or VF) and non-arrhythmic mortality in patients with a low LVEF. Accordingly, we are presenting a prediction model that integrates the risk of VT/VF with the risk of non-arrhythmic mortality in all 4531 patients with an ICD enrolled in the landmark MADIT trials (MADIT-II, MADIT-RISK, MADIT-CRT, and MADIT-RIT). We believe that our proposed MADIT-ICD Benefit Score can be used for shared decision-making in ICD candidates with a low LVEF.
Younis A, Goldberger JJ, Kutyifa V, Zareba W, Polonsky B, Klein H, Aktas MK, Huang D, Daubert J, Estes M, Cannom D, McNitt S, Stein K, Goldenberg I.