Plasmic Score for TTP

Predict ADAMTS13 deficiency in suspected thrombotic thrombocytopenic purpura (TTP) with high discrimination.

Plasmic Score for TTP

Predict ADAMTS13 deficiency in suspected thrombotic thrombocytopenic purpura (TTP) with high discrimination.

Plasmic Score for TTP

Predict ADAMTS13 deficiency in suspected thrombotic thrombocytopenic purpura (TTP) with high discrimination.

Plasmic Score for TTP

Predict ADAMTS13 deficiency in suspected thrombotic thrombocytopenic purpura (TTP) with high discrimination.

1.Platelet count < 30 x 10⁹/L?
2.Hemolysis?
3.Active cancer (or treated for active cancer in last year)?
4.History of solid organ or stem-cell transplant?
5.MCV < 90 fL (9.0 x 10⁻¹⁴/L)?
6.INR < 1.5?
7.Creatinine < 2.0 mg/dL / 176.8 umol/L?
Created by on 27/02/2020

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

About this Calculator

The PLASMIC Score was derived by Bendapudi et al and externally validated in a study with an independent cohort of 112 consecutive hospitalized patients with suspected thrombotic microangiopathy and appropriate ADAMTS-13 testing (including 21 patients with TTP diagnosis). The PLASMIC model predicted severe ADAMTS-13 deficiency with a c statistic of 0.94 (0.88-0.98). When dichotomized at high (scores 6-7) vs. low-intermediate risk (scores 0-5), the model predicted severe ADAMTS-13 deficiency with positive predictive value 72%, negative predictive value 98%, sensitivity 90% and specificity 92%.

In the low-intermediate risk group (scores 0-5), there was no significant improvement in overall survival associated with plasma exchange. The PLASMIC Score had excellent applicability, discrimination and calibration for predicting severe ADAMTS-13 deficiency. The clinical algorithm allowed identification of a subgroup of patients who lacked a significant response to empiric treatment.

References

Li A, Khalighi PR, Wu Q, Garcia DA.

External validation of the PLASMIC score: a clinical prediction tool for thrombotic thrombocytopenic purpura diagnosis and treatment.

Journal of Thrombosis and Haemostasis: JTH 2018, 16 (1): 164-169.

The Plasmic Score for TTP calculator is created by QxMD.

1. Platelet count < 30 x 10⁹/L?

Created by on 27/02/2020

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

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