Acute Gout Diagnosis Rule

Clinical decision tool to assist in the diagnosis of acute gout

Acute Gout Diagnosis Rule

Clinical decision tool to assist in the diagnosis of acute gout

Acute Gout Diagnosis Rule

Clinical decision tool to assist in the diagnosis of acute gout

Acute Gout Diagnosis Rule

Clinical decision tool to assist in the diagnosis of acute gout

1.Male Sex?
2.Previous patient-reported arthritis attack?
3.Onset within 1 day?
4.Joint redness?
5.1st Metatarsophalangeal joint involvement?
6.Hypertension or presence of ≥1 cardiovascular disease process?
7.Serum uric acid > 5.88 mg/dL / 0.35 mmol/L?
Created by on 16/08/2019

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

About this Calculator

The acute gout diagnostic rule was developed to assist clinicians in the diagnosis of gout in the absence of synovial fluid testing. It is a score based on history, physical exam, and laboratory parameters that create a clinical decision score to risk stratify patients based on study prevalence of confirmed gout by synovial fluid analysis as the gold standard.

The original criteria were derived in a primary care setting through regression analysis. 328 patients with suspected gout were assessed by family physicians and recruited to hospital setting for joint fluid analysis. The criteria found were to aimed to provide bedside utility in the absence of joint fluid aspirates. They found seven criteria of variable scoring weight within the clinical tool, of which low scores < 4 (2.2% prevalence of gout) and high scores ≥ 8 (82.5% prevalence of gout) provided the greatest utility.

The study criteria were validated in a secondary care setting (Rheumatology clinic) alongside joint aspirate testing. This demonstrated similar results to the derivation study and again allowed the greatest utility with low and high scores, offering an NPV of 95% for scores < 4 and a PPV of 87% for scores ≥ 8 respectively. This offers a useful diagnostic tool for clinicians to perform at the bedside when joint aspiration may be limited or deemed unnecessary prior to initiation of appropriate treatment.

Variable & Associated Points

  • Male Sex (+2)
  • Previous patient-reported arthritis attack (+2)
  • Onset within 1 day (+0.5)
  • Joint redness (+1)
  • 1st Metatarsophalangeal joint involvement (+2.5)
  • Hypertension or presence of ≥ 1 cardiovascular disease process (+1.5) Defined as Angina, MI, CHF, Stroke or TIA, PVD
  • Serum uric acid > 0.35 mmol/L (+3.5)

As per original study, patients with these scores had the following prevalence of gout:

  • Score ≤ 4 - 2.2%
  • Score > 4 and < 8 - 31.2%
  • Score ≥ 8 - 82.5%

References

Janssens HJ, Fransen J, van de Lisdonk EH et al.

A diagnostic rule for acute gouty arthritis in primary care without joint fluid analysis.

Arch Intern Med 2010;170:1120-6.

Keinhorst LBE, Janssens HJ, Fransen J, et al.

The validation of a diagnostic rule for gout without joint fluid analysis: a prospective study.

Rheumatology. 2015 Apr;54(4):609-14.

The Acute Gout Diagnosis Rule calculator is created by QxMD.

1. Male Sex?

Created by on 16/08/2019

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

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