Estimate risk of progression to AML in those with CMML using molecular genetics data


The CPSS-Mol is a new CMML-specific prognostic scoring system (CPSS) that incorporates molecular genetic data resulting in a 4-level integrated clinical/pathological/genetic risk stratification tool. This tool was derived from a cohort of European patients, 93% of whom possessed 1 of 38 somatic mutations. Based on multivariable Cox regression analyses, cytogenetic abnormalities and mutations in RUNX1, NRAS, SETBP1, and ASXL1 were independently associated with overall survival (OS). The CPSS-Mol fully retained its ability to risk stratify survival in an independent validation cohort of CMML patients.


The CMML CPSS-Mol calculator is created by QxMD.

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1. Cytogenetics

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