CMML CPSS-Mol

Estimate risk of progression to AML in those with CMML using molecular genetics data

CMML CPSS-Mol

Estimate risk of progression to AML in those with CMML using molecular genetics data

CMML CPSS-Mol

Estimate risk of progression to AML in those with CMML using molecular genetics data

CMML CPSS-Mol

Estimate risk of progression to AML in those with CMML using molecular genetics data

1.Cytogenetics
2.ASXL1
3.NRAS
4.RUNX1
5.SETBP1
6.BM blasts
7.WBC
8.Transfusions
Created by on 27/06/2019

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

About this Calculator

The CPSS-Mol is a new CMML-specific prognostic scoring system (CPSS) that incorporates molecular genetic data resulting in a 4-level integrated clinical/pathological/genetic risk stratification tool. This tool was derived from a cohort of European patients, 93% of whom possessed 1 of 38 somatic mutations. Based on multivariable Cox regression analyses, cytogenetic abnormalities and mutations in RUNX1, NRAS, SETBP1, and ASXL1 were independently associated with overall survival (OS). The CPSS-Mol fully retained its ability to risk stratify survival in an independent validation cohort of CMML patients.

References

The CMML CPSS-Mol calculator is created by QxMD.

1. Cytogenetics

Created by on 27/06/2019

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

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