Diagnosis of Progressive Supranuclear Palsy (PSP)

The 2017 Movement Disorder Society Criteria aim to improve upon previous diagnostic criteria by elucidating the distinct subtypes of the disease. All patients must have sporadic presentation after the age of 40 and subsequently progress. The criteria rest upon four clinical domains: oculomotor dysfunction, postural instability, akinesia, and cognitive dysfunction. Definite PSP can only be diagnosed upon autopsy, but the clinical criteria aim to diagnose 'Probable PSP' with a high degree of specificity. The category of 'Possible PSP' is has high sensitivity, but this comes at the cost of specificity. The least specific category is 'Suggestive of PSP'. The omission of limb dystonia as an aspect of corticobasal syndrome was corrected in a subsequent publication by the authors.