NSAID risk of AKI or hyperkalemia

Calculator to predict risk of AKI or hyperkalemia within 30 days after initiation of prescription NSAIDs in adults 66 years and older.


NSAIDs can put patients at risk of acute kidney injury. This calculator to estimate patients' risk of acute kidney injury or hyperkalemia within 30 days following initiation of a prescription NSAID was developed in a large retrospective population-based study of adults 66 years and older using linked administrative and laboratory databases in Ontario, Canada.

Acute kidney injury was defined as a serum creatinine increase of 50% or more, or an absolute increase of at least 0.3 mg/dL (26.5 umol/L).

Hyperkalemia was defined as serum potassium concentration of 5.5 mmol/L or greater.

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1. Age

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