MDS Revised - International Prognostic Scoring System (IPSS-R) Non-Age Adjusted

Assess mortality and progression to acute myeloid leukemia in myelodysplastic syndrome using the non-age adjusted model


The Revised IPSS (IPSS-R) was developed using a multivariate analysis of survival and freedom from progression to acute myeloid leukaemia in seven thousand and twelve patients with untreated de novo myelodysplastic syndromes.

Scores for each of five disease features were used to generate five prognostic categories. While patient age, performance status, ferritin, and lactate dehydrogenase were significantly associated with survival, they were not associated with risk of acute myeloid leukemia transformation.

In comparison with the original IPSS, the IPSS-R has one additional risk category, an additional two cytogenetic risk categories, splits the lower marrow blast percentages, and includes the severity of cytopenias. The IPSS-R offers more precise prognostic values than the original IPSS.

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1. Marrow Blasts?

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