CRRT Dosing Calculator
Calculate desired dose of dialysate in CRRT
About
Dosage in continuous renal replacement therapy (CRRT) has been assessed in multiple randomized controlled trials and two meta-analyses. Results from these studies indicate that higher intensity dialysis did not result in improved survival or clinical benefits.
The 2012 KDIGO guideline recommends delivering an effluent volume of 20 to 25 mL/kg per hour. It also notes that this generally requires prescription of a higher effluent volume to achieve the targeted dose of therapy.
References
Bouman CS, Oudemans-Van Straaten HM, Tijssen JG, Zandstra DF, Kesecioglu J.
Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G.
Saudan P, Niederberger M, De Seigneux S, Romand J, Pugin J, Perneger T, Martin PY.
Tolwani AJ, Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM.
Jun M, Heerspink HJ, Ninomiya T, Gallagher M, Bellomo R, Myburgh J, Finfer S, Palevsky PM, Kellum JA, Perkovic V, Cass A.
Van Wert R, Friedrich JO, Scales DC, Wald R, Adhikari NK, University of Toronto Acute Kidney Injury Research Group.
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