CRRT Dosing Calculator

Calculate desired dose of dialysate in CRRT

About

Dosage in continuous renal replacement therapy (CRRT) has been assessed in multiple randomized controlled trials and two meta-analyses. Results from these studies indicate that higher intensity dialysis did not result in improved survival or clinical benefits.

The 2012 KDIGO guideline recommends delivering an effluent volume of 20 to 25 mL/kg per hour. It also notes that this generally requires prescription of a higher effluent volume to achieve the targeted dose of therapy.

References

Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G.

Lancet 2000 July 1, 356 (9223): 26-30

Saudan P, Niederberger M, De Seigneux S, Romand J, Pugin J, Perneger T, Martin PY.

Kidney International 2006, 70 (7): 1312-7

Tolwani AJ, Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM.

Journal of the American Society of Nephrology: JASN 2008, 19 (6): 1233-8

Jun M, Heerspink HJ, Ninomiya T, Gallagher M, Bellomo R, Myburgh J, Finfer S, Palevsky PM, Kellum JA, Perkovic V, Cass A.

Clinical Journal of the American Society of Nephrology: CJASN 2010, 5 (6): 956-63

Van Wert R, Friedrich JO, Scales DC, Wald R, Adhikari NK, University of Toronto Acute Kidney Injury Research Group.

Critical Care Medicine 2010, 38 (5): 1360-9

The CRRT Dosing Calculator calculator is created by QxMD.

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1. Patient Weight?

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