CRRT Dosing Calculator

Calculate desired dose of dialysate in CRRT


Dosage in continuous renal replacement therapy (CRRT) has been assessed in multiple randomized controlled trials and two meta-analyses. Results from these studies indicate that higher intensity dialysis did not result in improved survival or clinical benefits.

The 2012 KDIGO guideline recommends delivering an effluent volume of 20 to 25 mL/kg per hour. It also notes that this generally requires prescription of a higher effluent volume to achieve the targeted dose of therapy.


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Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure.

Kidney International 2006, 70 (7): 1312-7

Tolwani AJ, Campbell RC, Stofan BS, Lai KR, Oster RA, Wille KM.

Standard versus high-dose CVVHDF for ICU-related acute renal failure.

Journal of the American Society of Nephrology: JASN 2008, 19 (6): 1233-8

Jun M, Heerspink HJ, Ninomiya T, Gallagher M, Bellomo R, Myburgh J, Finfer S, Palevsky PM, Kellum JA, Perkovic V, Cass A.

Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis.

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Van Wert R, Friedrich JO, Scales DC, Wald R, Adhikari NK, University of Toronto Acute Kidney Injury Research Group.

High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis.

Critical Care Medicine 2010, 38 (5): 1360-9

The CRRT Dosing Calculator calculator is created by QxMD.

Created by on 17/06/2016

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