CLL-IPI

The International Prognostic Index for patients with chronic lymphocytic leukemia

Questions

1.Age?
2.Binet B/C or Rai I-IV?
3.Beta-2 Microglobulin?
4.IGHV Unmutated?
5.Deletion 17p (FISH) and/or TP53 mutation (sequencing)?

About

The CLL-IPI allows more individualized management of CLL patients in clinical practice (cf. The International CLL-IPI working group; The Lancet Oncology 2016).

This risk score separates four risk groups with significantly different OS at five years: low (93.2%), intermediate (79.3%), high (63.3%), and very high risk (23.3%).

It was developed using the individual patient data of eight phase-III clinical trials from France, Germany, UK, USA and Poland comprising 3472 treatment-naive patients and validated in multiple independent cohorts of CLL patients from Mayo Clinic and Sweden. The proposal and validation was conducted by the International CLL-IPI working group. Results of the index should be used for risk-stratification and patient counseling but should not be used as a way to determine the need for treatment which should be based on the iWCLL criteria (Blood 111:5446). Estimates of survival were based on assessment of patients treated prior to the current era of targeted signaling inhibitors. Therefore, these predictions should be applied with caution to individual patients and are meant to help in decision making.

References

da Cunha-Bang C, Christiansen I, Niemann CU.

The International prognostic Index for patients with chronic lymphocytic leukemia (CLL-IPI) applied in a population-based cohort.

Blood 2016 October 27, 128 (17): 2181-2183

Gentile M, Shanafelt TD, Rossi D, et al.

Validation of the CLL-IPI and comparison with the MDACC prognostic index: analysis of 1364 newly diagnosed patients.

Blood 2016 October 20, 128 (16): 2093-2095

The CLL-IPI calculator is created by QxMD.

Created by on 01/09/2015

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1. Age?

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