Kinetic eGFR (KeGFR)

Estimate GFR when creatinine is changing acutely (either rising or falling)

Questions

1.Steady State Plasma Creatinine?
2.Creatinine Clearance or eGFR at baseline?
3.Creatine at 1st Time Point?
4.Creatinine at 2nd Time Point?
5.Time Interval Between Two Creatinine Values?

The kinetic eGFR (KeGFR) formula estimates renal function ie GFR in the setting of a changing serum creatinine as it is often desirable to estimate renal function at the bedside to assess acute kidney injury (AKI) or renal recovery.

Current eGFR equations can be used to estimate kidney function when the plasma creatinine is stable, but are not appropriate if the plasma creatinine is changing rapidly.

In the acute setting, the KeGFR formula is proposed, and only requires several variables that are easily obtained from clinical laboratory data.

The formula is derived from the initial creatinine content, volume of distribution, creatinine production rate, and the difference between consecutive plasma creatinines over a given time. The additional formula variables needed are any steady-state plasma creatinine, the corresponding eGFR, and the maximum increase in creatinine per day if anuric. While the maximum rise in creatinine per day can be variable, for the purpose of this took, we have utilized a fixed value of 1.5 mg/dL or 132 µmol/L.

KeGFR = [Steady-State Plasma Creatinine X Creatinine Clearance/Mean Plasma Creatinine] X ( 1 - [(24 X Delta Plasma Creatinine)/(Delta Time (h) X Max Delta Plasma creatinine/day)] )

The full derivation of the KeGFR formula can be reviewed here.

References

Chen S.

Retooling the Creatinine Clearance Equation to Estimate Kinetic GFR when the Plasma Creatinine Is Changing Acutely.

Journal of the American Society of Nephrology: JASN 2013, 24 (6): 877-88

The Kinetic eGFR (KeGFR) calculator is created by QxMD.

Created by on 23/03/2016

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.