Multiple Myeloma Prognosis (R-ISS)

Revised international staging system for myeloma


The Revised International Staging System (R-ISS) includes variables included in the original ISS (serum beta-2 microglobulin and serum albumin), while also including the additional prognostic information obtained from serum LDH and high-risk chromosomal abnormalities detected by interphase fluorescent in situ hybridization (iFISH) after CD138 plasma cell purification.

The revised ISS stages are as follows:

  • Stage I: ISS stage I and standard-risk CA by iFISH and normal LDH
  • Stage II: Not R-ISS stage I or III
  • Stage III: ISS stage III and either high-risk CA by iFISH or high LDH


Palumbo A et al.

Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2015 September 10, 33 (26): 2863-9

The Multiple Myeloma Prognosis (R-ISS) calculator is created by QxMD.

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1. Β₂-microglobulin?

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