NAFLD Fibrosis Score

Reduce the need for liver biopsy by identifying patients with non-alcoholic fatty liver disease likely or unlikely to have advanced fibrosis


The NAFLD fibrosis score is used to distinguish between patients with nonalcoholic fatty liver disease who have (F3-F4) and do not have (F0-F2) advanced fibrosis.

This scoring system had an area under the ROC curve of 0.88 (95% CI 0.85-0.92).

The regression formula for prediction of severity of fibrosis is based on 6 variables: age (years), BMI(kg/m2), IFG/diabetes, AST/ALT ratio, platelet count and albumin (g/dl).

2 cutoff points were selected to identify the presence (> 0.676) and absence (< -1.455) of significant fibrosis.

  • < -1.455: predictor of absence of significant fibrosis (F0-F2 fibrosis), negative predictive value 93%
  • between -1.455 and 0.675: indeterminate score
  • >0.675: predictor of presence of significant fibrosis (F3-F4 fibrosis), positive predictive value of 90%


Angulo P, Hui JM, Marchesini G et al.

Hepatology: Official Journal of the American Association for the Study of Liver Diseases 2007, 45 (4): 846-54

The NAFLD Fibrosis Score calculator is created by QxMD.

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