NAFLD Fibrosis Score
Reduce the need for liver biopsy by identifying patients with non-alcoholic fatty liver disease likely or unlikely to have advanced fibrosis
About
The NAFLD fibrosis score is used to distinguish between patients with nonalcoholic fatty liver disease who have (F3-F4) and do not have (F0-F2) advanced fibrosis.
This scoring system had an area under the ROC curve of 0.88 (95% CI 0.85-0.92).
The regression formula for prediction of severity of fibrosis is based on 6 variables: age (years), BMI(kg/m2), IFG/diabetes, AST/ALT ratio, platelet count and albumin (g/dl).
2 cutoff points were selected to identify the presence (> 0.676) and absence (< -1.455) of significant fibrosis.
- < -1.455: predictor of absence of significant fibrosis (F0-F2 fibrosis), negative predictive value 93%
- between -1.455 and 0.675: indeterminate score
- >0.675: predictor of presence of significant fibrosis (F3-F4 fibrosis), positive predictive value of 90%
References
Angulo P, Hui JM, Marchesini G et al.
The NAFLD fibrosis score A noninvasive system that identifies liver fibrosis in patients with NAFLD.
Hepatology: Official Journal of the American Association for the Study of Liver Diseases 2007, 45 (4): 846-54
The NAFLD Fibrosis Score calculator is created by QxMD.
By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.