Assess disease activity in lupus


The SLEDAI was originally developed to determine disease activity in patients with lupus.

SLEDAI-2K was developed as a modification of SLEDAI in order to include persistent, active disease in those descriptors that had previously only considered new or recurrent occurrences. Specifically SLEDAI-2K allows persistent active disease in alopecia, mucous membrane ulcers, rash, and proteinuria to be scored.

SLEDAI-2K was validated against the original SLEDAI as a predictor for mortality and as a measure of global disease activity. It was also found to be equivalent to SLEDAI in describing changes in disease activity from one visit to the next.


Gladman DD, Ibañez D, Urowitz MB.

Journal of Rheumatology 2002, 29 (2): 288-91

Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH, and the Committee on Prognosis Studies in SLE.

The development and validation of the SLE Disease Activity Index (SLEDAI). Arthritis Rheum 1992;35:630-40.

The SLEDAI-2K calculator is created by QxMD.

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1. Seizure?

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Recent onset, exclude metabolic, infectious or drug causes

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