FIB-4 for Noninvasive Diagnosis of Hepatic Fibrosis

Non-invasively identify hepatic fibrosis

FIB-4 for Noninvasive Diagnosis of Hepatic Fibrosis

Non-invasively identify hepatic fibrosis

FIB-4 for Noninvasive Diagnosis of Hepatic Fibrosis

Non-invasively identify hepatic fibrosis

FIB-4 for Noninvasive Diagnosis of Hepatic Fibrosis

Non-invasively identify hepatic fibrosis

1.Age?
2.AST?
3.Platelet Count?
4.ALT?
Created by on 05/00/2016

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About this Calculator

In Sterling et al, which studied patients co-infected with HIV and Hepatitis C, a simple, non-invasive index (FIB-4) was developed to identify significant hepatic fibrosis.

The formula for FIB-4 is: Age ([yr] x AST [U/L]) / ((PLT [10(9)/L]) x (ALT [U/L])(1/2)).

The AUROC of the index was 0.765 for differentiation between Ishak stage 0-3 and 4-6. At a cutoff of <1.45 in the validation set, the negative predictive value to exclude advanced fibrosis (stage 4-6) was 90% with a sensitivity of 70%. A cutoff of >3.25 had a positive predictive value of 65% and a specificity of 97%. Using these cutoffs, 87% of the 198 patients with FIB-4 values outside 1.45-3.25 would be correctly classified, and liver biopsy could be avoided in 71% of the validation group.

References

Sterling RK, Lissen E, Clumeck N, et. al.

Development of a simple noninvasive index to predict significant fibrosis patients with HIV/HCV co-infection.

Hepatology: Official Journal of the American Association for the Study of Liver Diseases 2006, 43 (6): 1317-25

The FIB-4 for Noninvasive Diagnosis of Hepatic Fibrosis calculator is created by QxMD.

1. Age?

Years
Created by on 05/00/2016

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

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