DAS28-ESR for Rheumatoid Arthritis

Assess disease activity in rheumatoid arthritis.

DAS28-ESR for Rheumatoid Arthritis

Assess disease activity in rheumatoid arthritis.

DAS28-ESR for Rheumatoid Arthritis

Assess disease activity in rheumatoid arthritis.

DAS28-ESR for Rheumatoid Arthritis

Assess disease activity in rheumatoid arthritis.

1.Tender Joint Count?
2.Swollen Joint Count?
3.ESR?
4.Patient Global Health?
Created by on 11/09/2015

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

About this Calculator

The development of the DAS (Disease Activity Score) was important because it provided a global summative and continuous score for disease activity assessment.

The original DAS was modified into the DAS28, and is felt to be considerably more practical. The DAS28 eliminated the grading of joints and reduced the number of joints evaluated to 28. It has largely replaced the traditional DAS in clinical trials and in practice.

Evaluation of response to a treatment can be made much easier and more objective using the DAS28. The DAS provides a score between 0 and 10, a larger number indicating more active disease.

When using the score to assess response to treatment, a DAS-28 reduction by 0.6 represents a moderate improvement, while a reduction more than 1.2 represents a major improvement.

Score interpretation

  • <2.6 suggests disease remission.
  • 2.6-3.2 suggests low disease activity
  • >3.2-5.1 suggests moderate disease activity
  • >5.1 suggest high disease activity

It should be noted that almost 15% of patients with DAS28 scores of 2.6 (the cut-point for remission) continue to have at least two swollen joints; some may have more than 10 swollen joints yet still be categorized as in "remission" using this composite index.

References

Aletaha D, Ward MM, Machold KP et. al.

Remission and active disease in rheumatoid arthritis: defining criteria for disease activity states.

Arthritis and Rheumatism 2005, 52 (9): 2625-36

van der Heijde DM, van 't Hof M, van Riel PL, van de Putte LB.

Development of a disease activity score based on judgment in clinical practice by rheumatologists.

Journal of Rheumatology 1993, 20 (3): 579-81

The DAS28-ESR for Rheumatoid Arthritis calculator is created by QxMD.

1. Tender Joint Count?

More Information

28 joints are assessed, including:

Shoulders, Elbows, Knees
In the hands: first through fifth metacarpophalangeal joint, the interphalangeal joint of the thumb, and the second through fifth proximal interphalangeal joint.

Created by on 11/09/2015

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

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