Calcium Correction for Hypoalbuminemia

Adjust serum calcium in the setting of low albumin

Calcium Correction for Hypoalbuminemia

Adjust serum calcium in the setting of low albumin

Calcium Correction for Hypoalbuminemia

Adjust serum calcium in the setting of low albumin

Calcium Correction for Hypoalbuminemia

Adjust serum calcium in the setting of low albumin

1.Serum calcium (total)?
2.Serum albumin?
Created by on 29/11/2015

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About this Calculator

Measured total calcium in serum consists of about 15% bound to organic and inorganic anions, about 40% bound to albumin, and the remaining as biologically active ionized calcium.

Therefore, serum total calcium may underestimate biologically active calcium levels in the hypoalbuminemic patient.

The adjustment formula is as follows:

  • Corrected Calcium mg/dL = (0.8 * (Normal Albumin - Pt's Albumin)) + Serum Ca
  • Corrected Calcium mmol/L = (0.02 * (Normal Albumin - Pt's Albumin)) + Serum Ca;

Please note that this adjustment formula has been shown to inaccurate in patients with chronic kidney disease and end-stage renal disease

References

Payne RB, Little AJ, Williams RB, Milner JR.

Interpretation of serum calcium in patients with abnormal serum proteins.

British Medical Journal (1857-1980) 1973 December 15, 4 (5893): 643-6

Gauci C1, Moranne O, Fouqueray B, de la Faille R, Maruani G, Haymann JP, Jacquot C, Boffa JJ, Flamant M, Rossert J, Urena P, Stengel B, Souberbielle JC, Froissart M, Houillier P.

Pitfalls of measuring total blood calcium in patients with CKD.

Journal of the American Society of Nephrology: JASN 2008, 19 (8): 1592-8

The Calcium Correction for Hypoalbuminemia calculator is created by QxMD.

1. Serum calcium (total)?

Created by on 29/11/2015

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

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