Adult Onset Still's Disease, Diagnostic Criteria

Diagnose Adult Onset Still's Disease.

Adult Onset Still's Disease, Diagnostic Criteria

Diagnose Adult Onset Still's Disease.

Adult Onset Still's Disease, Diagnostic Criteria

Diagnose Adult Onset Still's Disease.

Adult Onset Still's Disease, Diagnostic Criteria

Diagnose Adult Onset Still's Disease.

1.Fever ≥39°C lasting ≥1 week?
2.Arthralgias or arthritis lasting ≥2 weeks?
3.A nonpruritic macular or maculopapular skin rash that is salmon-colored in appearance and usually found over the trunk or extremities during febrile episodes?
4.Leukocytosis (≥10,000/mL), with ≥80 % granulocytes?
5.Sore throat?
6.Lymphadenopathy?
7.Hepatomegaly or splenomegaly?
8.Abnormal liver function studies, particularly elevations in aspartate and alanine aminotransferase and lactate dehydrogenase concentrations?
9.Negative tests for antinuclear antibody and rheumatoid factor?
Created by on 07/00/2016

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

About this Calculator

Establishing the diagnosis of Adult Onset Still's Disease is challenging given the absence of specific diagnostic tests. While many diagnostic criteria have been proposed, the Yamagushi criteria have the highest sensitivity.

The Yamaguchi criteria require the presence of five features, with at least two being major diagnostic criteria.

Major criteria:

  • Fever of at least 39°C lasting at least one week
  • Arthralgias or arthritis lasting two weeks or longer
  • A nonpruritic macular or maculopapular skin rash that is salmon-colored in appearance and usually found over the trunk or extremities during febrile episodes
  • Leukocytosis (10,000/mL or greater), with at least 80 percent granulocytes

Minor criteria:

  • Sore throat
  • Lymphadenopathy
  • Hepatomegaly or splenomegaly
  • Abnormal liver function studies, particularly elevations in aspartate and alanine aminotransferase and lactate dehydrogenase concentrations
  • Negative tests for antinuclear antibody and rheumatoid factor

References

Yamaghuchi et al.

Preliminary criteria for classification of adult Still's disease.

Journal of Rheumatology 1992, 19 (3): 424-30

The Adult Onset Still's Disease, Diagnostic Criteria calculator is created by QxMD.

1. Fever ≥39°C lasting ≥1 week?

Created by on 07/00/2016

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

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