MDS Revised - International Prognostic Scoring System (IPSS-R)

Assess mortality and progression to acute myeloid leukemia in myelodysplastic syndrome


Myelodysplastic syndromes are a heterogeneous group of diseases with variable outcomes. To refine the original IPSS, international MDS databases were combined for analysis (yielding a total population of n=7012). Modeling of prognostic risk was based on multivariate analysis of survival time and time to AML transformation.

Bone marrow cytogenetics, marrow blast percentage, and cytopenias remained the basis of the revised IPSS, but with refinement of the category thresholds and addition of age, performance status, serum ferritin, and LDH.


Greenberg et al.

Blood 2012 September 20, 120 (12): 2454-65

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1. Age

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