Mortality in IPF (GAP Index)
Estimate mortality in idiopathic pulmonary fibrosis
This equation is taken from Ley et al (2012). The GAP Index was derived and validated based on 558 patients with idiopathic pulmonary fibrosis (IPF) from three academic centers in the United States and Italy. The GAP Index was validated at both presentation and during follow-up and can therefore be used throughout the disease course. Additional scoring systems have been developed in IPF, but are not validated, include more complex variables, or lack stage-specific management recommendations.
Clinical implications for the GAP Index were suggested by the authors as follows:
- Close monitoring (every 6 mo) for evidence of disease progression
- Aggressive management of symptoms and comorbid conditions
- May not require immediate listing for lung transplantation
- Close monitoring (every 3–6 mo) for evidence of disease progression
- Consider listing for lung transplantation based on patient preferences, and evidence of disease progression
- Consider immediate listing for lung transplantation if appropriate or palliative care referral
Ley B et al.
Annals of Internal Medicine 2012 May 15, 156 (10): 684-91
T E King, J A Tooze, M I Schwarz, K R Brown, R M Cherniack
American Journal of Respiratory and Critical Care Medicine 2001 October 1, 164 (7): 1171-81
Wells AU et al.
American Journal of Respiratory and Critical Care Medicine 2003 April 1, 167 (7): 962-9
du Bois RM et al.
American Journal of Respiratory and Critical Care Medicine 2011 August 15, 184 (4): 459-66
The Mortality in IPF (GAP Index) calculator is created by QxMD.