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This formula is taken from Celli et al (2004), based on the evaluation of 207 patients with COPD and the subsequent prospective validation on a similar cohort of 625 patients. Patients were recruited in the United States, Venezuela, and Spain and all were judged to have stable COPD.
61% of deaths were secondary to respiratory insufficiency. Multiple variables were assessed and each was evaluated as a possible independent predictor of mortality. FEV1, body-mass index, 6-minute walk distance, and the modified MRC dyspnea scale were found to be the best predictors of death among these variables. The BODE Index predicts all-cause mortality and respiratory-related mortality with better accuracy than the FEV1 alone.
The hazard ratio for all-cause mortality is 1.34 for every one-point increase in the BODE score. The hazard ratio for respiratory-related mortality is 1.62 for every one-point increase in the BODE score.
Celli BR et al. The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease. NEJM 2004;350:1005.
Celli BR et al. Predictors of Survival in COPD: More than Just the FEV1. Respir Med 2008;102(Suppl 1):S27.