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Most Read Papers - Gastroenter...
Most Read Papers - Gastroenterology
• Most Read Papers - Gastroenterology
#1
JOURNAL ARTICLE
Muhammad Haseeb, Jagpreet Chhatwal, Jade Xiao, Pichamol Jirapinyo, Christopher C Thompson
IMPORTANCE: Obesity is a disease with a large socioeconomic burden. Endoscopic sleeve gastroplasty (ESG) is a minimally invasive endoscopic bariatric procedure with wide global adoption. More recently, new weight-loss medications, such as glucagon-like peptide-1 receptor agonists (eg, semaglutide), have attracted increased attention due to their efficacy. However, their cost-effectiveness over an extended period compared with ESG is a critical gap that needs to be better explored for informed health care decision-making...
April 1, 2024: JAMA Network Open
#2
REVIEW
Rohit Goyal, Amrit K Kamboj, Diana L Snyder
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated esophageal disorder. Given its increasing incidence, it is now a leading cause of dysphagia and food impaction in the United States. Eosinophilic esophagitis is most common in adult White men and has a high concurrence rate with other atopic conditions like allergic rhinitis, bronchial asthma, and eczema. The initial presentation includes symptoms of esophageal dysfunction, classically solid-food dysphagia. Without treatment, inflammation can progress to fibrosis with the formation of strictures, leading to complications such as food impaction...
April 2024: Mayo Clinic Proceedings
#3
Paola Soriani, Paolo Biancheri, Giuliano Francesco Bonura, Tommaso Gabbani, Enrique Rodriguez de Santiago, Lorenzo Dioscoridi, Gianluca Andrisani, Carmelo Luigiano, Simona Deiana, Joachim Rainer, Mariagrazia Del Buono, Rocco Amendolara, Massimiliano Marino, Cesare Hassan, Alessandro Repici, Mauro Manno
BACKGROUND: First-line over-the-scope-clip (OTSC) treatment has shown higher efficacy than standard endoscopic therapy in acute non-variceal upper gastrointestinal bleeding (UGIB) from different causes. We performed a head-to-head randomized controlled trial (RCT) comparing OTSC vs through-the-scope-clip (TTSC) as first-line mechanical treatment in the specific setting of peptic ulcer (PU) bleeding. METHODS: We conducted an international, multicenter RCT on consecutive patients with suspected UGIB...
April 10, 2024: Endoscopy
#4
JOURNAL ARTICLE
The Role of the Gastroenterologist in Obesity Management: Now Is the Right Time for Our Involvement.
Stephanie L Gold, Asher Kornbluth
No abstract text is available yet for this article.
April 8, 2024: American Journal of Gastroenterology
#5
JOURNAL ARTICLE
Abid Suddle, Helen Reeves, Richard Hubner, Aileen Marshall, Ian Rowe, Dina Tiniakos, Stefan Hubscher, Mark Callaway, Dinesh Sharma, Teik Choon See, Maria Hawkins, Suzanne Ford-Dunn, Sarah Selemani, Tim Meyer
Deaths from the majority of cancers are falling globally, but the incidence and mortality from hepatocellular carcinoma (HCC) is increasing in the United Kingdom and in other Western countries. HCC is a highly fatal cancer, often diagnosed late, with an incidence to mortality ratio that approaches 1. Despite there being a number of treatment options, including those associated with good medium to long-term survival, 5-year survival from HCC in the UK remains below 20%. Sex, ethnicity and deprivation are important demographics for the incidence of, and/or survival from, HCC...
April 16, 2024: Gut
#6
JOURNAL ARTICLE
Tanawat Geeratragool, Uayporn Kaosombatwattana, Arpapun Boonchote, Suvikrom Chatthammanat, Nutchanun Preechakawin, Jompol Srichot, Asawin Sudcharoen, Pavapol Sirisunhirun, Panotpol Termsinsuk, Manus Rugivarodom, Julajak Limsrivilai, Monthira Maneerattanaporn, Nonthalee Pausawasdi, Somchai Leelakusolvong
BACKGROUND & AIMS: High-dose proton pump inhibitor (PPI) therapy has been recommended to prevent rebleeding of high-risk peptic ulcer (PU) after hemostasis. Vonoprazan has been proven to be noninferior to PPIs in various acid-related diseases. This study aims to compare the efficacy of vonoprazan versus PPI for preventing high-risk PU rebleeding after hemostasis. METHODS: A multicenter, randomized, noninferiority study was conducted in 6 centers. Pre-endoscopic and endoscopic therapy were performed according to standard protocol...
April 5, 2024: Gastroenterology
#7
JOURNAL ARTICLE
Shankar Kumar, Isabelle De Kock, William Blad, Richard Hare, Richard Pollok, Stuart A Taylor
Magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) have developed rapidly in the last few decades, emerging as the primary non-invasive options for both diagnosing and monitoring Crohn's disease (CD). In this review, we evaluate the pertinent data relating to the use of MRE and IUS in CD. We summarise the key imaging features of CD activity, highlight their increasing role in both the clinical and research settings, and discuss how these modalities fit within the diagnostic pathway. We discuss how they can be used to assess disease activity and treatment responsiveness, including the emergence of activity scores for standardised reporting...
March 30, 2024: Journal of Crohn's & Colitis
#8
REVIEW
Chuandong Zhang, Yuqi Chen, Yan Long, Huimin Zheng, Jiyong Jing, Wensheng Pan
Helicobacter pylori ( H pylori ), a gastric bacterium, has been extensively studied for its association with gastritis, peptic ulcers, and gastric cancer. However, recent evidence suggests its potential implications beyond the stomach, linking it to other gastrointestinal malignancies, such as esophageal cancer, liver cancer, pancreatic cancer, gallbladder cancer, and colorectal cancer. In light of the expanding research landscape and the increasing interest in exploring H pylori broader role in gastrointestinal tumorigenesis, this comprehensive review aims to elucidate the relationship between H pylori and gastrointestinal tumors...
2024: Clinical Medicine Insights. Oncology
#9
JOURNAL ARTICLE
Ignacio Hanna-Jairala, Douglas A Drossman
Irritable bowel syndrome are responsive to treatments using central neuromodulators. Central neuromodulators work by enhancing the synaptic transmission of 5-hydroxytryptamine, noradrenalin and dopamine, achieving a slower regulation or desensitization of their postsynaptic receptors. Central neuromodulators act on receptors along the brain-gut axis, so they are useful in treating psychiatric comorbidities, modifying gut motility, improving central downregulation of visceral signals and enhancing neurogenesis in patients with IBS...
April 9, 2024: American Journal of Gastroenterology
#10
EDITORIAL
Rakhi Maiwall, Satender Pal Singh, Paolo Angeli, Richard Moreau, Aleksander Krag, Virender Singh, Ashwani K Singal, S S Tan, Puneet Puri, Mamun Mahtab, George Lau, Qin Ning, Manoj Kumar Sharma, P N Rao, Dharmesh Kapoor, Subhash Gupta, Ajay Duseja, Manav Wadhawan, Dinesh Jothimani, Sanjiv Saigal, Sunil Taneja, Akash Shukla, Pankaj Puri, Deepak Govil, Gaurav Pandey, Kaushal Madan, C E Eapen, Jaya Benjamin, Ashok Chowdhury, Shweta Singh, Vaishali Salao, Jin Mo Yang, Saeed Hamid, Shalimar, Sanjiv Jasuja, Anand V Kulkarni, Madund A Niriella, Harsh Vardhan Tevethia, Vinod Arora, R P Mathur, Akash Roy, Ankur Jindal, Neeraj Saraf, Nipun Verma, Arka De, Narendra S Choudhary, Rohit Mehtani, Phool Chand, Omkar Rudra, Shiv Kumar Sarin
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a high risk of short-term early death. The main causes of organ failure in these patients are bacterial infections and systemic inflammation, both of which can be severe. For the majority of these patients, a prompt liver transplant is still the only effective course of treatment. Kidneys are one of the most frequent extrahepatic organs that are affected in patients with ACLF, since acute kidney injury (AKI) is reported in 22...
April 5, 2024: Hepatology International
#11
REVIEW
Jonel Trebicka, Ruben Hernaez, Debbie Lindsay Shawcross, Alexander L Gerbes
The progression of cirrhosis with clinically significant portal hypertension towards decompensated cirrhosis remains clinically challenging and the evolution towards acute-on-chronic liver failure (ACLF), with one or more extrahepatic organ failures, is associated with very high mortality. In the last decade, significant progress has been made in the understanding of the mechanisms leading to decompensation and ACLF. As portal hypertension advances, bacterial translocation across an impaired gut barrier culminates in endotoxaemia, systemic inflammation and cirrhosis-associated immune dysfunction (CAID)...
March 25, 2024: Gut
#12
REVIEW
Danielle Adebayo, Florence Wong
BACKGROUND: Better understanding of disease pathophysiology has led to advances in managing ascites and its associated complications including hepatorenal syndrome-acute kidney Injury (HRS-AKI), especially medicinal and interventional advances. AIM: To review the latest changes in the management of ascites and HRS-AKI. METHODS: A literature search was conducted in Pubmed, using the keywords cirrhosis, ascites, renal dysfunction, acute kidney injury, hepatorenal syndrome, beta-blockers, albumin, TIPS and vasoconstrictors, including only publications in English...
March 25, 2024: Alimentary Pharmacology & Therapeutics
#13
JOURNAL ARTICLE
Arvind J Trindade
No abstract text is available yet for this article.
May 2024: Gastrointestinal Endoscopy
#14
JOURNAL ARTICLE
Massimiliano di Pietro, Nigel J Trudgill, Melina Vasileiou, Gaius Longcroft-Wheaton, Alexander W Phillips, James Gossage, Philip V Kaye, Kieran G Foley, Tom Crosby, Sophie Nelson, Helen Griffiths, Muksitur Rahman, Gill Ritchie, Amy Crisp, Stephen Deed, John N Primrose
Barrett's oesophagus is the only known precursor to oesophageal adenocarcinoma, a cancer with very poor prognosis. The main risk factors for Barrett's oesophagus are a history of gastro-oesophageal acid reflux symptoms and obesity. Men, smokers and those with a family history are also at increased risk. Progression from Barrett's oesophagus to cancer occurs via an intermediate stage, known as dysplasia. However, dysplasia and early cancer usually develop without any clinical signs, often in individuals whose symptoms are well controlled by acid suppressant medications; therefore, endoscopic surveillance is recommended to allow for early diagnosis and timely clinical intervention...
March 29, 2024: Gut
#15
JOURNAL ARTICLE
Georgia Malamut, Craig R Soderquist, Govind Bhagat, Nadine Cerf-Bensussan
Non-responsive celiac disease (NRCD) is relatively common. It is generally attributed to persistent gluten exposure and resolves after correction of diet errors. However, other complications of CD and disorders clinically mimicking CD, need to be excluded. Novel therapies are being evaluated to facilitate mucosal recovery, which might benefit NRCD patients. Refractory CD (RCD) is rare and is currently divided into two types. The etiology of RCD type 1 (RCDI) is unclear, a possible switch to gluten-independent autoimmunity is suspected in some patients, while RCD type II (RCDII) represents a low-grade intraepithelial lymphoma...
March 29, 2024: Gastroenterology
#16
JOURNAL ARTICLE
Mais Khasawneh, Christopher J Black, Alexander C Ford
No abstract text is available yet for this article.
March 16, 2024: Gastroenterology
#17
REVIEW
Xian Zhu, Jianwei Shen
Gastroesophageal reflux disease (GERD) is one of the most common diseases seen by gastroenterologists worldwide. A significant proportion of patients have a suboptimal response to acid inhibitors, especially proton pump inhibitors and potassium-competitive acid blockers. Due to concerns regarding the safety of long-term medication, many patients are unwilling to take lifelong medication. Endoscopic antireflux management offers a minimally invasive option for GERD patients. In recent decades, there have been several endoscopic antireflux therapies, including radiofrequency therapy, transoral fundoplication, and mucosal resection or mucosal ablation...
March 18, 2024: European Journal of Medical Research
#18
JOURNAL ARTICLE
Mohammad Tabish, Samagra Agarwal, Srikanth Gopi, Randeep Rana, Syed Ahmed, Deepak Gunjan, Sanchit Sharma, Anoop Saraya
OBJECTIVE: Limited evidence exists on the optimal strategy to correct iron deficiency anaemia(IDA) after variceal bleeding(VB) in cirrhosis. This trial compared the efficacy and safety of intravenous ferric-carboxymaltose (IV-FCM) with that of oral iron therapy in this cohort. DESIGN: In this open-label single center randomized controlled trial, eligible patients with hemoglobin <10 gm/dL and iron deficiency(Ferritin <100 ng/ml) after VB received either IV-FCM (1500-2000 mg) divided into two doses(n=48) or oral Carbonyl iron(100 mg elemental iron/day)(n=44) for 3 months...
March 22, 2024: American Journal of Gastroenterology
#19
JOURNAL ARTICLE
Amrit K Kamboj, Dhyanesh A Patel, Rena Yadlapati
No abstract text is available yet for this article.
March 9, 2024: Clinical Gastroenterology and Hepatology
#20
JOURNAL ARTICLE
Emma Vanderschueren, Angelo Armandi, Wilhelmus Kwanten, David Cassiman, Sven Francque, Jörn M Schattenberg, Wim Laleman
INTRODUCTION: The Baveno VI criteria have set the stage for noninvasive assessment of compensated advanced chronic liver disease (ACLD). The algorithm combining liver stiffness measurement (LSM, <20 kPa) and platelet count (>150,000/μL) safely avoids screening endoscopy for varices needing treatment (VNT) but identifies only a relatively low number of patients. We aimed to evaluate the value of spleen stiffness measurement (SSM) using spleen-dedicated elastography in ruling out VNT...
March 20, 2024: American Journal of Gastroenterology
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