Once Daily Foscarnet is Effective for HHV-6 Reactivation after Hematopoietic Stem Cell Transplantation.

BACKGROUND: Human herpesvirus 6 (HHV-6) reactivation is common after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is associated with higher mortality and transplant-related complications.

OBJECTIVES: We hypothesized that preemptive treatment with short course of foscarnet at lower cut point of plasma HHV-6 viral load would be effective in treating early HHV-6 reactivation, prevent complications and hospitalization of these patients.

METHODS: We reviewed outcomes of adult patients (18 years or older) who received preemptive treatment with once daily foscarnet 60-90 mg/kg for 7 days for HHV-6 reactivation after allo-HSCT at our institution between 05/2020-11/2022. Plasma HHV-6 viral load was monitored using quantitative polymerase chain reaction twice monthly in the first 100 days post-transplant and twice weekly after reactivation until resolution.

RESULTS: Eleven patients with a median age of 46 years (range, 23-73) were included in the analysis. Ten patients received HSCT from a haploidentical and one patient from HLA matched related donor. The most common diagnosis was acute leukemia (9 cases). Myeloablative- and reduced-intensity conditioning regimens were used in 4 cases and 7 cases, respectively. Most patients (10/11) received post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis. Median follow-up was 440 days (range, 174-831). Median time to HHV-6 reactivation was 22 days post-transplantation (range, 15-89), median level of viral load 3,100 copies/mL (range, 210-118,000) at first reactivation and median peak viral load was 11,300 copies/mL (range, 600-983,000). All patients received a short course of foscarnet of 90 mg/kg/day (N=7) and 60 mg/kg/day (N=4). Plasma HHV-6 DNA in all patients became undetected after completion of one week treatment. No HHV-6 encephalitis or pneumonitis occurred. All patients achieved neutrophil and platelet engraftment after a median time of 16 (range, 8-22) and 26 (range, 14-168) days, respectively, with no secondary graft failure. No complications related to foscarnet administration were noted. One patient with very high HHV-6 viremia had recurrent reactivation and received a second course of foscarnet as outpatient.

CONCLUSIONS: Short course of once daily foscarnet is effective in treating early HHV-6 reactivation post-transplant, may reduce incidence of HHV-6-related and treatment-related complications, and prevent hospitalization in these patients.