Marion Desdouits, Sandie Munier, Marie-Christine Prevost, Patricia Jeannin, Gillian Butler-Browne, Simona Ozden, Antoine Gessain, Sylvie Van Der Werf, Nadia Naffakh, Pierre-Emmanuel Ceccaldi
Besides the classical respiratory and systemic symptoms, unusual complications of influenza A infection in humans involve the skeletal muscles. Numerous cases of acute myopathy and/or rhabdomyolysis have been reported, particularly following the outbreak of pandemic influenza A(H1N1) in 2009. The pathogenesis of these influenza-associated myopathies (IAM) remains unkown, although the direct infection of muscle cells is suspected. Here, we studied the susceptibility of cultured human primary muscle cells to a 2009 pandemic and a 2008 seasonal influenza A(H1N1) isolate...
2013: PloS One