Rajendra A Badwe, Vani Parmar, Nita Nair, Shalaka Joshi, Rohini Hawaldar, Suraj Pawar, Geeta Kadayaprath, Bibhuti B Borthakur, Subramanyeshwar Rao Thammineedi, Shashank Pandya, Satheesan Balasubramanian, Priyadarshan V Chitale, Rakesh Neve, Caleb Harris, Anurag Srivastava, Shabina Siddique, Vaibhav J Vanmali, Ashwini Dewade, Varsha Gaikwad, Sudeep Gupta
PURPOSE: Preventing metastases by using perioperative interventions has not been adequately explored. Local anesthesia blocks voltage-gated sodium channels and thereby prevents activation of prometastatic pathways. We conducted an open-label, multicenter randomized trial to test the impact of presurgical, peritumoral infiltration of local anesthesia on disease-free survival (DFS). METHODS: Women with early breast cancer planned for upfront surgery without prior neoadjuvant treatment were randomly assigned to receive peritumoral injection of 0...
June 20, 2023: Journal of Clinical Oncology