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Most Read Papers - Surgery - Surgical Oncology

https://read.qxmd.com/read/37023374/effect-of-peritumoral-infiltration-of-local-anesthetic-before-surgery-on-survival-in-early-breast-cancer
#1
RANDOMIZED CONTROLLED TRIAL
Rajendra A Badwe, Vani Parmar, Nita Nair, Shalaka Joshi, Rohini Hawaldar, Suraj Pawar, Geeta Kadayaprath, Bibhuti B Borthakur, Subramanyeshwar Rao Thammineedi, Shashank Pandya, Satheesan Balasubramanian, Priyadarshan V Chitale, Rakesh Neve, Caleb Harris, Anurag Srivastava, Shabina Siddique, Vaibhav J Vanmali, Ashwini Dewade, Varsha Gaikwad, Sudeep Gupta
PURPOSE: Preventing metastases by using perioperative interventions has not been adequately explored. Local anesthesia blocks voltage-gated sodium channels and thereby prevents activation of prometastatic pathways. We conducted an open-label, multicenter randomized trial to test the impact of presurgical, peritumoral infiltration of local anesthesia on disease-free survival (DFS). METHODS: Women with early breast cancer planned for upfront surgery without prior neoadjuvant treatment were randomly assigned to receive peritumoral injection of 0...
June 20, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/38445909/comparison-of-conventional-unstained-lymph-nodal-harvesting-vs-methylene-blue-stained-lymph-nodal-harvesting-in-colorectal-specimen-in-staging-left-sided-colorectal-carcinoma-a-randomized-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Suresh Chilaka, Evangeline Mary Kiruba Samuel, Naveen Naik Mude, Balasubramanian G, Bhawana Badhe, Raj Kumar Nagarajan
BACKGROUND: The management and prognosis of colorectal carcinomas (CRCs) are related to the stage of the disease, which, in turn, relies on the lymph node harvest from the surgical specimen. The guidelines recommend that at least 12 lymph nodes are required, which is not achieved in most resections. In this study, we propose a method to improve the lymph node yield in such cases. This study aimed to determine whether ex vivo injection of methylene blue into the inferior mesenteric artery or its branches improves lymph node retrieval in left-sided CRCs...
March 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/28758147/create-x-a-role-for-capecitabine-in-early-stage-breast-cancer-an-analysis-of-available-data
#3
REVIEW
Jo Anne Zujewski, Lawrence Rubinstein
Breast cancer patients with residual disease after neoadjuvant chemotherapy and surgery may benefit from additional anti-cancer therapies. Capecitabine, an oral antimetabolite and prodrug of 5-Flurouracil, has been approved for treating metastatic breast cancer. One randomized clinical trial (CREATE-X) of capecitabine versus no additional therapy has been conducted in women with early stage breast cancer who received standard chemotherapy pre-operative therapy and had residual invasive breast cancer at the time of surgery...
2017: NPJ Breast Cancer
https://read.qxmd.com/read/38488204/real-world-practice-and-outcomes-in-pilonidal-surgery-pilonidal-sinus-treatment-studying-the-options-pitstop-cohort
#4
JOURNAL ARTICLE
Steven R Brown, Daniel Hind, Emily Strong, Mike Bradburn, Farhat Din, Ellen Lee, Jon Lund, Christine Moffatt, Jonathan Morton, Asha Senapati, Helen Jones, Matthew J Lee
BACKGROUND: Numerous surgical approaches exist for the treatment of pilonidal disease. Current literature on treatment is of poor quality, limiting the ability to define optimal intervention. The aim of this study was to provide real-world data on current surgical practice and report patient and risk-adjusted outcomes, informing future trial design. METHODS: This UK-wide multicentre prospective cohort study, including patients (aged over 16 years) who had definitive treatment for symptomatic pilonidal disease, was conducted between May 2019 and March 2022...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38473302/ctdna-for-the-evaluation-and-management-of-egfr-mutant-non-small-cell-lung-cancer
#5
REVIEW
Aakash Desai, Tadana A Vázquez, Keishla M Arce, Marcelo Corassa, Philip C Mack, Jhanelle E Gray, Bruna Pellini
Circulating tumor DNA (ctDNA) offers a new paradigm in optimizing treatment strategies for epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). Its potential spans early-stage disease, influencing adjuvant therapy, to advanced disease, where it aids in identifying genomic markers and resistance mechanisms. This review explores the evolving landscape of utilizing liquid biopsies, specifically circulating tumor DNA (ctDNA), in the management of NSCLC with EGFR mutations. While tissue-based genomic testing remains the cornerstone for clinical decision-making, liquid biopsies offer a well-validated, guideline-recommended alternative approach...
February 26, 2024: Cancers
https://read.qxmd.com/read/38418633/score-prediction-of-anastomotic-leak-in-colorectal-surgery-a-systematic-review
#6
REVIEW
Alexis Litchinko, Nicolas Buchs, Alexandre Balaphas, Christian Toso, Emilie Liot, Guillaume Meurette, Frédéric Ris, Jeremy Meyer
OBJECTIVE: Predicting the risk of anastomotic leak (AL) is of importance when defining the optimal surgical strategy in colorectal surgery. Our objective was to perform a systematic review of existing scores in the field. METHODS: We followed the PRISMA checklist (S1 Checklist). Medline, Cochrane Central and Embase were searched for observational studies reporting on scores predicting AL after the creation of a colorectal anastomosis. Studies reporting only validation of existing scores and/or scores based on post-operative variables were excluded...
February 28, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38488815/rintatolimod-in-advanced-pancreatic-cancer-enhances-anti-tumor-immunity-through-dendritic-cell-mediated-t-cell-responses
#7
JOURNAL ARTICLE
Casper W F van Eijck, Hassana El Haddaoui, Songul Kucukcelebi, Disha Vadgama, Amine Fellah, Dana A M Mustafa, Joachim G J V Aerts, Casper H J van Eijck, Marcella Willemsen
PURPOSE: Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a toll-like receptor 3 (TLR-3) agonist, is a potential candidate due to its dual impact on restraining PDAC cell functions and boosting the anti-tumor immune response. This study investigates the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of advanced PDAC patients. PATIENTS AND METHODS: Paired blood samples of 30 patients with advanced PDAC, collected at baseline and after 12 rintatolimod intravenous infusions, underwent comprehensive transcriptomic NanoString and proteomic flow cytometry profiling...
March 15, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38476085/exploration-of-immune-cell-heterogeneity-by-single-cell-rna-sequencing-and-identification-of-secretory-leukocyte-protease-inhibitor-as-an-oncogene-in-pancreatic-cancer
#8
JOURNAL ARTICLE
Bolun Ai, Yicheng Liang, Tao Yan, Yangyang Lei
Clinical outcomes remain unsatisfactory in patients with pancreatic cancer (PAC). In this study, through single-cell sequencing, we identified eight cell subpopulations in the tumor microenvironment (TME). Redimensional clustering of epithelial cells, myeloid cells, and cancer-associated fibroblasts (CAFs) revealed heterogeneity in the TME of PAC. Intercellular communication analysis showed strong direct interactions between matrix CAFs, inflammatory CAFs, and epithelial cells. Additionally, we found that the SPP1-associated pathway was activated in monocytes, whereas the vascular endothelial growth factor-associated pathway was activated in epithelial cells...
March 13, 2024: Environmental Toxicology
https://read.qxmd.com/read/37003891/coffee-administration-to-promote-return-of-bowel-function-after-small-bowel-resection-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Conor Holland, Lynn Shaffer, Elliot Dobkin, Jamie Hall
BACKGROUND: Prolonged ileus occurs in 10%-24% of patients undergoing abdominal surgery. Several trials have found coffee administration reduces postoperative ileus, but this has not been evaluated for small bowel resection. METHODS: Following small bowel resection, patients were randomized to caffeinated coffee or warm water three times a day until the time of first flatus or first bowel movement. Primary outcomes were time from end of procedure to: 1) nasogastric tube removal; and 2) when the discharge order was written...
August 2023: American Journal of Surgery
https://read.qxmd.com/read/38401422/best-of-the-year-advanced-breast-cancer-in-2023
#10
REVIEW
Ilana Schlam, Mariana Chavez-MacGregor
No abstract text is available yet for this article.
February 14, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38431994/the-significance-of-resection-margins-on-r0-results-in-intrahepatic-cholangiocarcinoma
#11
JOURNAL ARTICLE
B O Stüben, S Ahmadi, F H Saner, J Li, J P Neuhaus, J W Treckmann, D P Hoyer
BACKGROUND: Intrahepatic cholangiocarcinoma is the second most common primary liver cancer after hepatocellular carcinoma with an increasing incidence worldwide. Surgical resection is still the only potential cure, and survival rates are dismal due to disease relapse after resection and/or metastatic disease. Positive resection margins are associated with recurrence, with conflicting studies regarding the benefits of wide resection margins to reduce recurrence rates. METHODS: 126 patients with an R0 resection treated with hepatic surgery for intrahepatic cholangiocarcinoma at the Surgical Department at the Medical University Centre Essen, Germany were identified in a database and retrospectively analysed...
February 29, 2024: Surgical Oncology
https://read.qxmd.com/read/38390259/management-of-acral-lentiginous-melanoma-current-updates-and-future-directions
#12
REVIEW
Michelle M Dugan, Matthew C Perez, Lilit Karapetyan, Jonathan S Zager
Acral lentiginous melanoma is a rare subtype of melanoma generally associated with poor outcomes, even when diagnosed at an early stage. The tumor genetic profile remains poorly understood, but it is known to have a suppressed immune environment compared to that of non-acral cutaneous melanomas, which limits therapy options. There is significant attention on the development of novel therapeutic approaches, although studies are limited due to disease rarity. For local disease, wide local excision remains the standard of care...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38125917/her2-early-breast-cancer-from-escalation-via-targeted-and-post-neoadjuvant-treatment-to-de-escalation
#13
REVIEW
Monika Graeser, Oleg Gluz
BACKGROUND: Human epidermal growth factor receptor 2 positive (HER2+, also referred to as ERBB2+) breast cancer is a subtype, historically associated with a particularly poor prognosis. Research into biological and molecular pathomechanisms of breast cancer has resulted in the development and adoption of several therapies targeting HER2. In parallel, various escalation/de-escalation strategies have been examined to further optimize patient outcomes and care. SUMMARY: In this review, we highlighted the landmark trials in the evolution of treatment and management of HER2+ early breast cancer (eBC)...
December 2023: Breast Care
https://read.qxmd.com/read/38449909/recent-advances-in-rectal-cancer-treatment-are-we-on-the-right-track
#14
REVIEW
Bengt Glimelius
BACKGROUND: Staging and treatment of rectal cancer have evolved over several decades with considerably fewer locoregional recurrences but no marked improved survival since systemic recurrence risks remain virtually unchanged. This development will briefly be summarised followed by a thorough discussion of two recent developments. METHODS: A systematic approach towards the literature is aimed at focusing on organ preservation and the delivery of all non-surgical treatments prior to surgery or total neoadjuvant treatment (TNT)...
2024: Upsala Journal of Medical Sciences
https://read.qxmd.com/read/38430428/initial-experience-using-laparoscopic-hipec-for-gastric-cancer-with-peritoneal-metastasis-safety-and-outcomes
#15
JOURNAL ARTICLE
Meagan D Read, Justin Drake, Ghazal Hashemipour, Benjamin D Powers, Rutika Mehta, Andrew Sinnamon, Jose M Pimiento, Sean P Dineen
BACKGROUND: Peritoneal metastases (PM) develop in approximately 20% of patients with gastric cancer (GC). For selected patients, treatment of PM with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has shown promising results. This report aims to describe the safety and perioperative outcomes of laparoscopic HIPEC for GC/PM. METHODS: This retrospective cohort study evaluated patients who had GC and PM treated with laparoscopic HIPEC (2018-2022)...
March 2, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38368292/oncological-safety-of-skipping-axillary-lymph-node-dissection-in-patients-with-clinical-n0-sentinel-node-positive-breast-cancer-undergoing-total-mastectomy
#16
JOURNAL ARTICLE
Jung Whan Chun, Eunhye Kang, Hong-Kyu Kim, Han-Byoel Lee, Hyeong-Gon Moon, Jong Won Lee, Wonshik Han
OBJECTIVE: This study aimed to determine whether sentinel lymph node biopsy (SLNB) alone could afford oncological outcomes comparable with axillary lymph node dissection (ALND) in patients with early breast cancer without palpable lymphadenopathy who underwent total mastectomy (TM) and were SLN-positive. METHODS: This study analyzed clinical data of 6747 patients with breast cancer who underwent TM between 2014 and 2018 in two tertiary hospitals in Korea. Overall, 643 clinical stage T1-3 N0 patients who did not receive neoadjuvant therapy and had one to two metastatic SLNs at the time of surgery were included...
February 17, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38377643/the-impact-of-methylene-blue-in-colorectal-cancer-systematic-review-and-meta-analysis-study
#17
REVIEW
Alexandre Carvalho, Nuno Gonçalves, Pedro Teixeira, André Goulart, Pedro Leão
PURPOSE: In patients with colorectal cancer (CRC), the most important factor to decide the need of adjuvant chemotherapy is the histological lymph node (LN) evaluation. Our work aimed to give a broad view over the use of methylene blue and its consequences in the number of lymph node harvest. METHODS: PUBMED, WEB OF SCIENCE and EMBASE databases were consulted, retrieving clinical trials, which mentioned the used of intra-arterial methylene blue in patients with colorectal cancer...
February 9, 2024: Surgical Oncology
https://read.qxmd.com/read/38173914/total-mesorectal-excision-with-or-without-lateral-pelvic-lymph-node-dissection-in-rectal-cancer
#18
JOURNAL ARTICLE
Mohamed Yehia Elbarmelgi, Ahmed Mohamed Abdelaal, Osama Refaie, Mohamed Tamer, Ali Ahmed Shafik
RESULTS: Incidence of local recurrence was slightly higher in Group A (8.7%) than in Group B (4.3%) but was not statistically significant. There was no statistical significance between both groups regarding distant metastasis (8.7% in Group A and 13% in Group B). Urinary and sexual dysfunctions were higher in Group B (26.1%) compared to those in Group A (21.7%) but were not statistically significant. The incidence of lateral pelvic lymph node metastasis was 30.4%. Also, intraoperative blood loss was higher and operative time was longer in Group B which was statistically significant ( P value <0...
2023: International Journal of Surgical Oncology
https://read.qxmd.com/read/38402268/early-versus-late-drainage-removal-in-patients-who-underwent-pancreaticoduodenectomy-a-comprehensive-systematic-review-and-meta-analysis-of-randomized-controlled-trials-using-trial-sequential-analysis
#19
JOURNAL ARTICLE
Claudio Ricci, Davide Giovanni Grego, Laura Alberici, Carlo Ingaldi, Stefano Togni, Ermenegilda De Dona, Riccardo Casadei
BACKGROUND: The superiority of early drain removal (EDR) versus late (LDR) after pancreaticoduodenectomy (PD) has been demonstrated only in RCTs. METHODS: A meta-analysis was conducted using a random-effects model and trial sequential analysis. The critical endpoints were morbidity, redrainage, relaparotomy, and postoperative pancreatic fistula (CR-POPF). Hemorrhage (PPH), delayed gastric emptying (DGE), length of stay (LOS), and readmission rates were also evaluated...
February 24, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38341286/european-fellowship-training-opportunities-for-hepato-pancreato-biliary-surgery-an-international-survey-of-fellows-and-program-directors
#20
JOURNAL ARTICLE
Giampaolo Perri, Ajith K Siriwardena, Stefan Gilg, Ernesto Sparrelid
BACKGROUND: There are no established training pathways for hepato-pancreato-biliary (HPB) surgery in Europe. This study aims to overview the current status of fellowship training from both fellows' and institutions' perspectives. METHODS: A web-based snapshot survey was distributed to all members of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA) to reach for former fellows and program directors of European HPB surgery fellowships held between 2013 and 2023...
February 1, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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