Hassan Al-Khalisy, Gary F Nieman, Michaela Kollisch-Singule, Penny Andrews, Luigi Camporota, Joseph Shiber, Toni Manougian, Joshua Satalin, Sarah Blair, Auyon Ghosh, Jacob Herrmann, David W Kaczka, Donald P Gaver, Jason H T Bates, Nader M Habashi
Acute respiratory distress syndrome (ARDS) alters the dynamics of lung inflation during mechanical ventilation. Repetitive alveolar collapse and expansion (RACE) predisposes the lung to ventilator-induced lung injury (VILI). Two broad approaches are currently used to minimize VILI: (1) low tidal volume (LVT ) with low-moderate positive end-expiratory pressure (PEEP); and (2) open lung approach (OLA). The LVT approach attempts to protect already open lung tissue from overdistension, while simultaneously resting collapsed tissue by excluding it from the cycle of mechanical ventilation...
January 18, 2024: Respiratory Research