REFERENCE BOOK
KDIGO Clinical Practice Guideline for Acute Kidney Injury
Research Recommendations
Research recommendations
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Randomized trials should compare unfractionated to low-molecular-weight heparin during IHD in patients with AKI.
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Randomized trials should compare unfractionated to low-molecular-weight heparin during CRRT in patients with AKI.
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Randomized trials should compare citrate to unfractionated to low-molecular-weight heparin during CRRT in patients with AKI.
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Future trials should compare a strategy without anticoagulation against one of anticoagulation during CRRT.
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Outcomes of interest for trials testing different anticoagulation strategies with RRT in AKI are clinical end-points, including bleeding, renal recovery, mortality, incidence of HIT, and surrogates such as circuit survival and efficiency of dialysis, metabolic complications, and effects on the coagulation system.
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