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In patients with AKI requiring RRT, the contact of blood with the foreign surface of the extracorporeal circuit results in activation of both the intrinsic and the extrinsic pathway of plasmatic coagulation and activation of platelets.571 Prevention of dialyzer/hemofilter clotting often requires some form of anticoagulation, which may represent a particular challenge in patients with AKI. The need for continuous anticoagulation represents a potential drawback of CRRT.
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