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Two studies fulfilled our inclusion criteria; one study459 showed a superiority of iodixanol vs. ioxaglate, but this was not confirmed in the study by Mehran et al.,460 who found no difference between these two contrast agents. Although overall the number of patients is substantial, there is heterogeneity among the comparators with which iodixanol has been compared. In addition, the cost of iodixanol is probably higher than the cost of most of the low-osmolar contrast agents. No studies comparing a possible difference among low-osmolar contrast media have been performed. Based on evidence profiles (Suppl Tables 19 and 20) and the most recent meta-analysis457 (Figure 14) of the studies comparing i.a. administration of iso- vs. low-osmolar contrast media, the Work Group found no evidence to recommend a preference for either type of agent.
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