REFERENCE BOOK
KDIGO Clinical Practice Guideline for Acute Kidney Injury
Research Recommendations
Research Recommendations
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The role of biomarkers other than SCr in the early diagnosis, differential diagnosis, and prognosis of AKI patients should be explored. Some important areas in which to focus include:
- Early detection where the gold standard is AKI by clinical diagnosis after the fact and the biomarker is compared to existing markers (SCr and urine output) at the time of presentation.
- Prognosis where a biomarker is used to predict risk for AKI or risk for progression of AKI.
- Prognosis where a biomarker is used to predict recovery after AKI vs. death or need for long-term RRT.
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The influence of urinary output criteria on AKI staging needs to be further investigated. Influence of fluid balance, percent volume overload, diuretic use, and differing weights (actual, ideal body weight, lean body mass) should be considered. Also, it is currently not known how urine volume criteria should be applied (e.g., average vs. persistent reduction for the period specified).
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The influence of SCr or eGFR criteria on AKI staging needs to be further investigated. The use of different relative and absolute SCr increments or eGFR decrements at different time points and with differently ascertained baseline values requires further exploration and validation in various populations.
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