KDIGO Clinical Practice Guideline for Acute Kidney Injury
Evidence selection, appraisal, and presentation

Evidence selection, appraisal, and presentation

We first defined the topics and goals for the guideline and identified key clinical questions for review. The ERT performed literature searches, organized abstract and article screening, coordinated methodological and analytic processes of the report, defined and standardized the search methodology, performed data extraction, and summarized the evidence. The Work Group members reviewed all included articles, data extraction forms, summary tables, and evidence profiles for accuracy and completeness. The four major topic areas of interest for AKI included: i) definition and classification; ii) prevention; iii) pharmacologic treatment; and iv) RRT. Populations of interest were those at risk for AKI (including those after intravascular contrast-media exposure, aminoglycosides, and amphotericin) and those with or at risk for AKI with a focus on patients with sepsis or trauma, receiving critical care, or undergoing cardiothoracic surgery. We excluded studies on AKI from rhabdomyolysis, specific infections, and poisoning or drug overdose. Overall, we screened 18 385 citations.