APRI (AST to Platelet Ratio Index)

Assess likelihood of fibrosis or cirrhosis non-invasively using AST and platelet count.


The AST to Platelet Ratio Index (APRI) tool has been found to useful as a non-invasive index that correlates with liver biopsy findings of fibrosis and cirrhosis.

In a meta-analysis by Lin et al, it was found that in patients with hepatitis C, an APRI score greater than 1.0 had a sensitivity of 76% and specificity of 72% for predicting cirrhosis. In addition, it was found that an APRI score greater than 0.7 had a sensitivity of 77% and specificity of 72% for predicting significant hepatic fibrosis.


Lin ZH, Xin YN, Dong QJ, et al.

Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis.

Hepatology: Official Journal of the American Association for the Study of Liver Diseases 2011, 53 (3): 726-36

The APRI (AST to Platelet Ratio Index) calculator is created by QxMD.

Created by on 05/01/2016

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1. AST?

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