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Base excess is defined as the amount of strong acid that must be added to each liter of fully oxygenated blood to return the pH to 7.40 at a temperature of 37°C and a pCO2 of 40 mmHg (5.3 kPa), while a base deficit (ie. a negative base excess) is defined by the amount of strong base that must be added.
The formula for base deficit is as follows:
Base excess = 0.02786 X pCO2 X 10^(pH - 6.1) + 13.77 X pH - 124.58
Reference
Siggaard-Andersen O.
An acid-base chart for arterial blood with normal and pathophysiological reference areas.
Scan J Clin Lab Invest. 27:239-245, 1971.
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