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In a toxic alcohol ingestion with ethylene glycol or methanol, dialysis is often required.
The duration of hemodialysis in hours required to achieve a toxin concentration of ≤5 mmol/L can be estimated using the formula [-V ln(5/A)]/0.06k, where V is total body water in liters, A is the initial alcohol concentration in mmol/L, and k is 80 percent of the dialyzer urea clearance in mL/min at the observed blood flow rate.
References
Hirsch DJ, Jindal KK, Wong P, Fraser AD
A simple method to estimate the required dialysis time for cases of alcohol poisoning
Kidney International 2001, 60 (5): 2021-4
Youssef GM, Hirsch DJ
Validation of a method to predict required dialysis time for cases of methanol and ethylene glycol poisoning.
Am J Kidney Dis. 2005;46(3):509.
McMurray M, Carty D, Toffelmire EB
Predicting methanol clearance during hemodialysis when direct measurement is not available.
CANNT J. 2002;12(1):29.
Burns AB, Bailie GR, Eisele G, McGoldrick D, Swift T, Rosano TG
Use of pharmacokinetics to determine the duration of dialysis in management of methanol poisoning.
Am J Emerg Med. 1998;16(5):538.
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