PERITONEAL MEMBRANE TYPE

Peritoneal Membrane Type is important to consider when individualizing patient prescriptions. The Peritoneal Equilibration Test (PET) is used to define the membrane transport characteristics. Four different membrane types are identified based upon the 4-hour equilibration between dialysate (D) and plasma (P) creatinine and glucose, as shown below.²⁵

Standardized PET Procedure²⁵

• In preparation for PET, an overnight dwell of 3-12 hours is required^25,26
• Drain pretest exchange completely
• Infuse 2.5% dextrose solution 2L bag
• Dialysis samples are taken after 0, 2 and 4 hours and analyzed for creatinine and glucose*/**
• A serum sample is taken after 2 hours and analyzed for creatinine and glucose*
• After a 4-hour dwell time, the dialysate is drained and total volume measured
• Based on results, the patient’s D/P for creatinine and D/D0 for glucose are calculated

The patient’s 4-hour D/P will classify the patient as a high, high-average, low-average or low transporter.

* Prescription management software may require serum and peritoneal dialysate urea measurement.
** If nonenzymatic method (i.e., picric acid assay) is used for analysis of creatinine, be sure to use correction factor to accurately estimate creatinine value.