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The original Schwartz eGFR formula was devised in the mid-1970s to estimate GFR in children. This model was felt to overestimates GFR, likely a result of a change in methods used to measure creatinine.
In 2009, Schwartz et al developed a revised estimated GFR formula using data from cohort of children in the Chronic Kidney Disease in Children (CKiD) study.
This model is appropriate for children between the ages of 1 to 16 yr.
The linear regression analyses generated a model that included the following:
height (meters)
serum creatinine (mg/dL)
cystatin C (mg/L)
Blood urea nitrogen (mg/dL)
Gender
The full equation is as follows:
GFR (ml/min per 1.73 m2) =
39.1[height/creatinine]0.516 X [1.8/cystatin C]0.294 [30/BUN]0.169 [1.099]male [height/1.4]0.188
Given the complexity of this formula, a "bedside" version requiring only height and creatinine was developed:
eGFR = 0.413 X (height/serum creatinine),
where height is in cm, andcreatinine is in mg/dL
References
Schwartz GJ1, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL.
New equations to estimate GFR in children with CKD.
J Am Soc Nephrol. 2009 Mar;20(3):629-37. doi: 10.1681/ASN.2008030287. Epub 2009 Jan 21.
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