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Establishing the diagnosis of Adult Onset Still's Disease is challenging given the absence of specific diagnostic tests. While many diagnostic criteria have been proposed, the Yamagushi criteria have the highest sensitivity.
The Yamaguchi criteria require the presence of five features, with at least two being major diagnostic criteria.
Major criteria:
Minor criteria:
Reference
Yamaghuchi et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol. 1992;19(3):424.
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