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The Sokal score was derived from 813 European and American patients treated from the 1960s-1980s, prior to the era of tyrosine kinase inhibitor therapy. Most individuals in the cohort were treated with single-agent chemotherapeutics. The EUTOS scoring system may offer improved prognostication in the era of TKI therapy
References
Sokal JE, Cox EB, Baccarani M, Tura S, Gomez GA, Robertson JE et al.
Prognostic discrimination in "good-risk" chronic granulocytic leukemia.
Circulation. 2011 May 24;123(20):2213-8. doi: 10.1161/CIRCULATIONAHA.110.988568. Epub 2011 May 9.
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