Here are the 100 articles that received the most attention in 2015 (as of December 15, 2015) by the ‘Read by QxMD’ community.

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Sinclair AJ1, Sturrock A2, Davies B3, Matharu M4. Headache management: pharmacological approaches. Pract Neurol. 2015 Dec;15(6):411-23. PMID: 26141299.

Qavi AH1, Kamal R1, Schrier RW2. Clinical Use of Diuretics in Heart Failure, Cirrhosis, and Nephrotic Syndrome. Int J Nephrol. 2015;2015:975934. PMID: 26294976.

Baraldi O1, Valentini C1, Donati G1, Comai G1, Cuna V1, Capelli I1, Angelini ML1, Moretti MI1, Angeletti A1, Piscaglia F1, La Manna G1. Hepatorenal syndrome: Update on diagnosis and treatment. World J Nephrol. 2015 Nov 6;4(5):511-20. PMID: 26558188.

Watson JC1, Dyck PJ2. Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management. Mayo Clin Proc. 2015 Jul;90(7):940-51. PMID: 26141332.

Ochiai R1. Mechanical ventilation of acute respiratory distress syndrome. J Intensive Care. 2015 May 29;3(1):25. PMID: 26045965.

Carville SF1, Henderson R2, Gray H3. The acute management of ST-segment-elevation myocardial infarction. Clin Med (Lond). 2015 Aug;15(4):362-7. PMID: 26407386.

Avni T1, Lador A1, Lev S2, Leibovici L1, Paul M3, Grossman A1. Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis. PLoS One. 2015 Aug 3;10(8):e0129305. PMID: 26237037.

Levy B1, Bastien O, Benjelid K, Cariou A, Chouihed T, Combes A, Mebazaa A, Megarbane B, Plaisance P, Ouattara A, Splaulding C, Teboul JL, Vanhuyse F, Boulain T, Kuteifan K. Experts' recommendations for the management of adult patients with cardiogenic shock. Ann Intensive Care. 2015 Dec;5(1):52. PMID: 26152849.

O'Connor A1, Gisbert JP2,3, O'Morain C4, Ladas S5. Treatment of Helicobacter pylori Infection 2015. Helicobacter. 2015 Sep;20 Suppl 1:54-61. PMID: 26372826.

Kannan L1, Figueredo VM. Images in clinical medicine. Wellens' syndrome. N Engl J Med. 2015 Jan 1;372(1):66. PMID: 25551527.


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Gupta RG1, Hartigan SM2, Kashiouris MG3, Sessler CN3, Bearman GM4. Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care. 2015 Aug 28;19:286. PMID: 26316210.

Hamm LL1, Nakhoul N2, Hering-Smith KS2. Acid-Base Homeostasis. Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2232-42. PMID: 26597304.

Authors/Task Force Members, Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2015 Aug 29. PMID: 26320110.

Kotecha D1, Piccini JP2. Atrial fibrillation in heart failure: what should we do? Eur Heart J. 2015 Dec 7;36(46):3250-7. PMID: 26419625.

Cahill TJ1, Prendergast BD2. Infective endocarditis. Lancet. 2015 Sep 1. PMID: 26341945.

Low PA1, Tomalia VA2. Orthostatic Hypotension: Mechanisms, Causes, Management. J Clin Neurol. 2015 Jul;11(3):220-6. PMID: 26174784.

Bazan IS1, Fares WH1. Pulmonary hypertension: diagnostic and therapeutic challenges. Ther Clin Risk Manag. 2015 Aug 17;11:1221-33. PMID: 26316767.

SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015 Nov 26;373(22):2103-16. PMID: 26551272.

Prina E1, Ranzani OT2, Torres A3. Community-acquired pneumonia. Lancet. 2015 Sep 12;386(9998):1097-108. PMID: 26277247.

Seymour CW1, Rosengart MR2. Septic Shock: Advances in Diagnosis and Treatment. JAMA. 2015 Aug 18;314(7):708-17. PMID: 26284722.


Nanayakkara S1, Kaye DM2. Management of Heart Failure With Preserved Ejection Fraction: A Review. Clin Ther. 2015 Oct 1;37(10):2186-98. PMID: 26385583.

Un H1, Dogan M2, Uz O2, Isilak Z2, Uzun M2. Novel vagal maneuver technique for termination of supraventricular tachycardias. Am J Emerg Med. 2015 Jun 3. PMID: 26209466.

Wichmann JL1, Katzberg RW1, Litwin SE1, Zwerner PL1, De Cecco CN1, Vogl TJ1, Costello P1, Schoepf UJ2. Contrast-Induced Nephropathy. Circulation. 2015 Nov 17;132(20):1931-6. PMID: 26572669.

Tong SY1, Davis JS2, Eichenberger E3, Holland TL3, Fowler VG Jr4. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015 Jul;28(3):603-61. PMID: 26016486.

Henry DA. In The Clinic: Hyponatremia. Ann Intern Med. 2015 Aug 4;163(3):ITC1-19. PMID: 26237763.

Moritz ML, Ayus JC. Maintenance Intravenous Fluids in Acutely Ill Patients. N Engl J Med. 2015 Oct;373(14):1350-60. PMID: 26422725.

Singh JA1, Saag KG1, Bridges SL Jr1, Akl EA2, Bannuru RR3, Sullivan MC3, Vaysbrot E3, McNaughton C3, Osani M3, Shmerling RH4, Curtis JR1, Furst DE5, Parks D6, Kavanaugh A7, O'Dell J8, King C9, Leong A10, Matteson EL11, Schousboe JT12, Drevlow B13, Ginsberg S14, Grober J13, St Clair EW15, Tindall E16, Miller AS17, McAlindon T3. 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Nov 6. PMID: 26545940.

Frerk C1, Mitchell VS2, McNarry AF3, Mendonca C4, Bhagrath R5, Patel A6, O'Sullivan EP7, Woodall NM8, Ahmad I9; Difficult Airway Society intubation guidelines working group. Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults†. Br J Anaesth. 2015 Dec;115(6):827-48. PMID: 26556848.

Atzema CL1, Barrett TW2. Managing atrial fibrillation. Ann Emerg Med. 2015 May;65(5):532-9. PMID: 25701296.

Semeraro N1, Ammollo CT1, Semeraro F1, Colucci M1. Coagulopathy of Acute Sepsis. Semin Thromb Hemost. 2015 Sep;41(6):650-8. PMID: 26305237.

Santos RS1, Silva PL1, Pelosi P1, Rocco PR1. Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way. World J Crit Care Med. 2015 Nov 4;4(4):278-86. PMID: 26557478.

Haugen BR Md1,2, Alexander EK3, Bible KC4, Doherty G5, Mandel SJ6, Nikiforov YE7, Pacini F8,9, Randolph G10, Sawka A11, Schlumberger M12, Schuff KG13, Sherman SI14, Sosa JA15, Steward D16, Tuttle RM Md17, Wartofsky L18. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2015 Oct 14. PMID: 26462967.

Ding M1, Satija A1, Bhupathiraju SN1, Hu Y1, Sun Q2, Han J3, Lopez-Garcia E4, Willett W2, van Dam RM5, Hu FB6. Association of Coffee Consumption with Total and Cause-Specific Mortality in Three Large Prospective Cohorts. Circulation. 2015 Nov 16. PMID: 26572796.

Peacock WF1, Cannon CM2, Singer AJ3, Hiestand BC4. Considerations for initial therapy in the treatment of acute heart failure. Crit Care. 2015 Nov 10;19:399. PMID: 26556500.

Koff RS1. Cirrhosis: A Practical Guide to Management. Gastroenterology. 2015 Jul 25. PMID: 26219482.

Greinacher A. CLINICAL PRACTICE. Heparin-Induced Thrombocytopenia. N Engl J Med. 2015 Jul 16;373(3):252-61. PMID: 26176382.

Kalogeropoulos AP1, Georgiopoulou VV1, Murphy RA2, Newman AB3, Bauer DC4, Harris TB2, Yang Z5, Applegate WB6, Kritchevsky SB6. Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) Study. JAMA Intern Med. 2015 Mar;175(3):410-9. PMID: 25599120.

Elbers P1, Rodrigus T, Nossent E, Malbrain ML, Vonk-Noordegraaf A. Fluid therapy in critically ill patients: perspectives from the right heart. Anaesthesiol Intensive Ther. 2015 Nov 18. PMID: 26578396.

Drawz P, Rahman M. Chronic kidney disease. Ann Intern Med. 2015 Jun 2;162(11):ITC1-16. PMID: 26030647.

European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Autoimmune hepatitis. J Hepatol. 2015 Oct;63(4):971-1004. PMID: 26341719.

Spandorfer J, Galanis T. In the Clinic. Deep venous thrombosis. Ann Intern Med. 2015 May 5;162(9):ITC1. PMID: 25939012.

O'Connor RE, Al Ali AS, Brady WJ, Ghaemmaghami CA, Menon V, Welsford M, Shuster M. Part 9: Acute Coronary Syndromes: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S483-500. PMID: 26472997.

Niederman MS. Community-Acquired Pneumonia. Ann Intern Med. 2015 Oct 6;163(7):ITC1. PMID: 26436631.

Halpern SD1. Toward Evidence-Based End-of-Life Care. N Engl J Med. 2015 Nov 19;373(21):2001-3. PMID: 26465826.

Rosenkranz S1, Gibbs JS2, Wachter R3, De Marco T4, Vonk-Noordegraaf A5, Vachiéry JL6. Left ventricular heart failure and pulmonary hypertension†. Eur Heart J. 2015 Oct 27. PMID: 26508169.

Toner P1, McAuley DF2,3, Shyamsundar M2,3. Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome. Crit Care. 2015 Oct 23;19:374. PMID: 26494395.

National Kidney Foundation. KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 Update. Am J Kidney Dis. 2015 Nov;66(5):884-930. PMID: 26498416.

[No authors listed] Use of the Title "Doctor" in the Clinical Setting. Ann Emerg Med. 2015 Dec;66(6):693. PMID: 26590755.

Cullen L1, Parsonage W2, Than M3. Myocardial infarction: rapid ruling out in the emergency room. Lancet. 2015 Oct 7. PMID: 26454363.

Neogi T1, Jansen TL2, Dalbeth N3, Fransen J4, Schumacher HR5, Berendsen D4, Brown M6, Choi H1, Edwards NL7, Janssens HJ4, Lioté F8, Naden RP9, Nuki G10, Ogdie A5, Perez-Ruiz F11, Saag K12, Singh JA13, Sundy JS14, Tausche AK15, Vaquez-Mellado J16, Yarows SA17, Taylor WJ6. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2015 Oct;74(10):1789-98. PMID: 26359487.

Buyon JP1, Cohen P2, Merrill JT3, Gilkeson G4, Kaplan M5, James J6, McCune WJ7, Bernatsky S8, Elkon K9. A highlight from the LUPUS 2014 meeting: eight great ideas. Lupus Sci Med. 2015 Jun 30;2(1):e000087. PMID: 26167290.

Koster RW1. Continuous or Interrupted Chest Compressions for Cardiac Arrest. N Engl J Med. 2015 Dec 3;373(23):2278-9. PMID: 26552007.

Fanaroff AC1, Rymer JA1, Goldstein SA2, Simel DL3, Newby LK4. Does This Patient With Chest Pain Have Acute Coronary Syndrome?: The Rational Clinical Examination Systematic Review. JAMA. 2015 Nov 10;314(18):1955-65. PMID: 26547467.

Pedro-Botet J1, Climent E1, Chillarón JJ1, Toro R2, Benaiges D1, Flores-Le Roux JA1. Statins for primary cardiovascular prevention in the elderly. J Geriatr Cardiol. 2015 Jul;12(4):431-8. PMID: 26345308.

Nienaber CA1, Clough RE2. Management of acute aortic dissection. Lancet. 2015 Feb 28;385(9970):800-11. PMID: 25662791.

Fox CS, Golden SH, Anderson C, Bray GA, Burke LE, de Boer IH, Deedwania P, Eckel RH, Ershow AG, Fradkin J, Inzucchi SE, Kosiborod M, Nelson RG, Patel MJ, Pignone M, Quinn L, Schauer PR, Selvin E, Vafiadis DK; American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Surgery and Anesthesia, Council on Quality of Care and Outcomes Research; American Diabetes Association. Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association. Diabetes Care. 2015 Sep;38(9):1777-803. PMID: 26246459.

Schrier SL1. So you know how to treat iron deficiency anemia. Blood. 2015 Oct 22;126(17):1971. PMID: 26494915.

Chertoff J1, Chisum M1, Garcia B2, Lascano J3. Lactate kinetics in sepsis and septic shock: a review of the literature and rationale for further research. J Intensive Care. 2015 Oct 6;3:39. PMID: 26445673.

Tho NV1, Park HY2, Nakano Y3. Asthma-COPD overlap syndrome (ACOS): A diagnostic challenge. Respirology. 2015 Oct 8. PMID: 26450153.

Page RL, Joglar JA, Caldwell MA, Calkins H, Conti JB, Deal BJ, Estes NA 3rd, Field ME, Goldberger ZD, Hammill SC, Indik JH, Lindsay BD, Olshansky B, Russo AM, Shen WK, Tracy CM, Al-Khatib SM. 2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2015 Sep 16. PMID: 26409258.

PMID: 26169648.

Kuhn T, Basch P, Barr M, Yackel T; Medical Informatics Committee of the American College of Physicians. Clinical documentation in the 21st century: executive summary of a policy position paper from the American College of Physicians. Ann Intern Med. 2015 Feb 17;162(4):301-3. PMID: 25581028.

Lankisch PG1, Apte M2, Banks PA3. Acute pancreatitis. Lancet. 2015 Jul 4;386(9988):85-96. PMID: 25616312.

Rocha LL1, Pessoa CM1, Corrêa TD1, Pereira AJ1, de Assunção MS1, Silva E2. Current concepts on hemodynamic support and therapy in septic shock. Braz J Anesthesiol. 2015 Sep-Oct;65(5):395-402. PMID: 26323739.

Karceski S. Dizziness as a sign of stroke. Neurology. 2015 Nov 24;85(21):e158-61. PMID: 26598440.

Vadmann H1, Nielsen PB1, Hjortshøj SP2, Riahi S2, Rasmussen LH3, Lip GY4, Larsen TB1. Atrial flutter and thromboembolic risk: a systematic review. Heart. 2015 Sep;101(18):1446-55. PMID: 26149627.

Kaafarani HM1. IMAGES IN CLINICAL MEDICINE. Tension Pneumoperitoneum. N Engl J Med. 2015 Nov 19;373(21):e24. PMID: 26581011.

Pakula AM1, Skinner RA2. Acute Kidney Injury in the Critically Ill Patient: A Current Review of the Literature. J Intensive Care Med. 2015 Mar 9. PMID: 25752308.

J Obstet Gynaecol Can. 2015 Jun;37(6):553-74. PMID: 26334607.

Poulter NR1, Prabhakaran D2, Caulfield M3. Hypertension. Lancet. 2015 Aug 22;386(9995):801-12. PMID: 25832858.

Sterns RH. Disorders of plasma sodium--causes, consequences, and correction. N Engl J Med. 2015 Jan 1;372(1):55-65. PMID: 25551526.


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Godoy DA1, Piñero GR1, Koller P1, Masotti L1, Di Napoli M1. Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage. World J Crit Care Med. 2015 Aug 4;4(3):213-29. PMID: 26261773.

Kraut JA1, Madias NE2. Metabolic Acidosis of CKD: An Update. Am J Kidney Dis. 2015 Oct 15. PMID: 26477665.

Dobson J1, Whitley RJ2, Pocock S1, Monto AS3. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet. 2015 May 2;385(9979):1729-37. PMID: 25640810.

Betjemann JP1, Lowenstein DH2. Status epilepticus in adults. Lancet Neurol. 2015 Jun;14(6):615-24. PMID: 25908090.

Ingelfinger JR. A new era for the treatment of hyperkalemia? N Engl J Med. 2015 Jan 15;372(3):275-7. PMID: 25415806.

Wenzel RP1, Edmond MB. Antibiotics for abdominal sepsis. N Engl J Med. 2015 May 21;372(21):2062-3. PMID: 25992751.

Alford EL1, Wheless JW2, Phelps SJ3. Treatment of Generalized Convulsive Status Epilepticus in Pediatric Patients. J Pediatr Pharmacol Ther. 2015 Jul-Aug;20(4):260-89. PMID: 26380568.

Batterink J1, Cessford TA, Taylor RA. Pharmacological interventions for the acute management of hyperkalaemia in adults. Cochrane Database Syst Rev. 2015 Oct 27;10:CD010344. PMID: 26506077.

Douketis JD, Spyropoulos AC, Kaatz S, Becker RC, Caprini JA, Dunn AS, Garcia DA, Jacobson A, Jaffer AK, Kong DF, Schulman S, Turpie AG, Hasselblad V, Ortel TL; BRIDGE Investigators. Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation. N Engl J Med. 2015 Aug 27;373(9):823-33. PMID: 26095867.

Djogovic D1, MacDonald S2, Wensel A2, Green R3, Loubani O3, Archambault P4, Bordeleau S4, Messenger D5, Szulewski A5, Davidow J1, Kircher J2, Gray S6, Smith K2, Lee J2, Marc Benoit J, Howes D5. Vasopressor and Inotrope Use in Canadian Emergency Departments: Evidence Based Consensus Guidelines. CJEM. 2015 Feb;17 Suppl 1:1-16. PMID: 26067924.

Kaukonen KM1, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015 Apr 23;372(17):1629-38. PMID: 25776936.

[No authors listed] Inflammatory Bowel Disease. Am J Gastroenterol. 2015 Oct;110 Suppl 1:S766-847. PMID: 26436816.

Romeo GR, Abrahamson MJ. The 2015 standards for diabetes care: maintaining a patient-centered approach. Ann Intern Med. 2015 Jun 2;162(11):785-6. PMID: 25798733.

Webster DP1, Klenerman P2, Dusheiko GM3. Hepatitis C. Lancet. 2015 Mar 21;385(9973):1124-35. PMID: 25687730.

Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med. 2015 Apr 16;372(16):1539-48. PMID: 25875259.

Kullberg BJ, Arendrup MC. Invasive Candidiasis. N Engl J Med. 2015 Oct 8;373(15):1445-56. PMID: 26444731.

Pivonello R1, De Leo M1, Cozzolino A1, Colao A1. The Treatment of Cushing's Disease. Endocr Rev. 2015 Aug;36(4):385-486. PMID: 26067718.

Bhandari S1, Ives N2, Brettell EA2, Valente M2, Cockwell P3, Topham PS4, Cleland JG5, Khwaja A6, El Nahas M6. Multicentre randomized controlled trial of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker withdrawal in advanced renal disease: the STOP-ACEi trial. Nephrol Dial Transplant. 2015 Sep 30. PMID: 26429974.

Nijs J1, Apeldoorn A, Hallegraeff H, Clark J, Smeets R, Malfliet A, Girbes EL, De Kooning M, Ickmans K. Low back pain: guidelines for the clinical classification of predominant neuropathic, nociceptive, or central sensitization pain. Pain Physician. 2015 May-Jun;18(3):E333-46. PMID: 26000680.

Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE, Bell D, Bion JF, Coats TJ, Singer M, Young JD, Rowan KM; ProMISe Trial Investigators. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015 Apr 2;372(14):1301-11. PMID: 25776532.

Fogel N1. Tuberculosis: a disease without boundaries. Tuberculosis (Edinb). 2015 Sep;95(5):527-31. PMID: 26198113.

Ansell SM1. Hodgkin Lymphoma: Diagnosis and Treatment. Mayo Clin Proc. 2015 Nov;90(11):1574-83. PMID: 26541251.

Harnik IG. In the Clinic. Gastroesophageal Reflux Disease. Ann Intern Med. 2015 Jul 7;163(1):ITC1. PMID: 26148292.

Strom BL1, Schinnar R2, Karlawish J3, Hennessy S2, Teal V4, Bilker WB2. Statin Therapy and Risk of Acute Memory Impairment. JAMA Intern Med. 2015 Aug;175(8):1399-405. PMID: 26054031.

Nieman LK1. Cushing's syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015 Oct;173(4):M33-8. PMID: 26156970.

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