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JOURNAL ARTICLE
META-ANALYSIS
REVIEW
Posterior reversible encephalopathy syndrome in pediatric patients: pathophysiology, diagnosis, and management.
Leukemia & Lymphoma 2019 October
Posterior reversible encephalopathy syndrome (PRES) is well-described in adults, but has been reported with relative rarity in children, usually occurring in the context of chemotherapy for acute leukemia. Pathogenesis involves perturbed cerebral autoregulation leading to vasogenic edema predominantly affecting the parieto-occipital white matter, though involvement of the frontal and temporal lobes, as well as posterior fossa, is also described. We review the literature on the pathophysiology, diagnosis, and management of PRES in pediatric patients.
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