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DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.

Hannes Hahne, Fiona Pachl, Benjamin Ruprecht, Stefan K Maier, Susan Klaeger, Dominic Helm, Guillaume Médard, Matthias Wilm, Simone Lemeer, Bernhard Kuster
Nature Methods 2013 October
We report that low percentages of dimethylsulfoxide (DMSO) in liquid chromatography solvents lead to a strong enhancement of electrospray ionization of peptides, improving the sensitivity of protein identification in bottom-up proteomics by up to tenfold. The method can be easily implemented on any LC-MS/MS system without modification to hardware or software and at no additional cost.

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